Going by what researchers at the University of California have discovered, a new kind of hazard score, which is a calculation based on 54 singular nucleotide poly-morphisms, are capable of predicting the age at which one is diagnosed for aggressive prostate cancer. This was later published in the BMJ.
- Two data sets with 6411 men and 31747 men were considered: The researchers started developing and validating a genetically functioning tool which predicts the age at which aggressive prostate cancer will be diagnosed. These were then combined in an analysis for survival. Singular nucleotide poly-morphisms, which were linked to the disease being diagnosed, were chosen by analyzing their genotypes and ages.
- Hazard score calculation done based on 54 singular nucleotide poly morphism is more accurate: While predicting the age of an individual when prostate cancer occurs, if the hazard scores are based upon 54 singular nucleotide poly morphisms, the results are more accurate. These values managed to predict the age at diagnosis of prostate cancer that is aggressive, and this was proved in the independently validated set. The ratio for hazards is around 2.9 and when compared to other cases where this system isn’t used, there is significant validation. In the former case, more than 98 percent were accurate while without this, the hazard score values were much less accurate.
- Inclusion of familial histories don’t improve the accuracy of predictions: Even when polygenic hazard scoring tests factored in signs seen in the history of the family, the prediction models were not as accurate. These hazard scores can be utilized to improve the ability to scan for the age at which one can be diagnosed.
Polygenetic hazardous scores can be used for the personalizing of genetic risk, and thus, prostate cancer can be predicted, though more research into this is needed.